Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

• Main Authors: Arik Dahan (Author), Daniel Porat (Author), Milica Markovic (Author), Moran Zur (Author), Olga Kister (Author), Peter Langguth (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bariatric surgery is an effective treatment for severe obesity and related comorbidities, such as type II diabetes. Gastric bypass surgery shortens the length of the intestine, possibly leading to altered drug absorption. Metformin, a first-line treatment for type II diabetes, has permeability-depen...