Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes

• Main Authors: Amy Lee Bredlau (Author), Anjan Motamarry (Author), Chao Chen (Author), M. A. McCrackin (Author), Kris Helke (Author), Kent E. Armeson (Author), Katrina Bynum (Author), Ann-Marie Broome (Author), Dieter Haemmerich (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Most drugs cannot penetrate the blood-brain barrier (BBB), greatly limiting the use of anti-cancer agents for brain cancer therapy. Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug in response to hyperthermia (>40 °C). Since hyperthermia also transie...