Development and validation of a yeast high-throughput screen for inhibitors of Aβ42 oligomerization

• Main Authors: Sei-Kyoung Park (Author), Scott D. Pegan (Author), Andrew D. Mesecar (Author), Lisa M. Jungbauer (Author), Mary Jo LaDu (Author), Susan W. Liebman (Author)
• Format: Book
• Published: The Company of Biologists, 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Recent reports point to small soluble oligomers, rather than insoluble fibrils, of amyloid β (Aβ), as the primary toxic species in Alzheimer's disease. Previously, we developed a low-throughput assay in yeast that is capable of detecting small Aβ42 oligomer formation. Specifically, Aβ42...