Amphiphilic Cell-Penetrating Peptides Containing Arginine and Hydrophobic Residues as Protein Delivery Agents

• Main Authors: Jonathan Moreno (Author), Khalid Zoghebi (Author), David Salehi (Author), Lois Kim (Author), Sorour Khayyatnejad Shoushtari (Author), Rakesh K. Tiwari (Author), Keykavous Parang (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The entry of proteins through the cell membrane is challenging, thus limiting their use as potential therapeutics. Seven cell-penetrating peptides, designed in our laboratory, were evaluated for the delivery of proteins. Fmoc solid-phase peptide synthesis was utilized for the synthesis of seven cycl...