Significance of interferon signaling based on mRNA-microRNA integration and plasma protein analyses in critically ill COVID-19 patients

• Main Authors: Yuki Togami (Author), Hisatake Matsumoto (Author), Jumpei Yoshimura (Author), Tsunehiro Matsubara (Author), Takeshi Ebihara (Author), Hiroshi Matsuura (Author), Yumi Mitsuyama (Author), Takashi Kojima (Author), Masakazu Ishikawa (Author), Fuminori Sugihara (Author), Haruhiko Hirata (Author), Daisuke Okuzaki (Author), Hiroshi Ogura (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We evaluated mRNA and miRNA in COVID-19 patients and elucidated the pathogenesis of COVID-19, including protein profiles, following mRNA and miRNA integration analysis. mRNA and miRNA sequencing was done on admission with whole blood of 5 and 16 healthy controls (HCs) and 10 and 31 critically ill CO...