Immunohistochemical staining of LEF-1 is a useful marker for distinguishing WNT-activated medulloblastomas

• Main Authors: Depeng Wang (Author), Jie Gong (Author), Hui Zhang (Author), Yulu Liu (Author), Nannan Sun (Author), Xiaomeng Hao (Author), Kun Mu (Author)
• Format: Book
• Published: BMC, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Objectives To investigate lymphoid enhancer factor 1 (LEF-1) protein expression in medulloblastomas (MBs) and its correlation with molecular grouping of MBs. Methods Expressions of LEF-1 and β-catenin were detected by immunohistochemistry, and molecular grouping was performed based on the N...