[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models

• Main Authors: Tuo Shao (Author), Zhen Chen (Author), Jian Rong (Author), Vasily Belov (Author), Jiahui Chen (Author), Andre Jeyarajan (Author), Xiaoyun Deng (Author), Hualong Fu (Author), Qingzhen Yu (Author), Steve H. Rwema (Author), Wenyu Lin (Author), Mikhail Papisov (Author), Lee Josephson (Author), Raymond T. Chung (Author), Steven H. Liang (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoacylglycerol lipase (MAGL) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol (2-AG) into the proinflammatory eicosanoid precursor arachidonic acid (AA). MAGL and other endogenous cannabinoid (EC) degrading enzymes are involved in the fibrogenic signaling...