Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats

• Main Authors: Toshikatsu Okumura (Author), Tsukasa Nozu (Author), Masatomo Ishioh (Author), Sho Igarashi (Author), Shima Kumei (Author), Masumi Ohhira (Author)
• Format: Book
• Published: Elsevier, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Short chain fatty acids readily crosses the gut-blood and blood-brain barrier and acts centrally to influence neuronal signaling. We hypothesized that butyrate, a short-chain fatty acid produced by bacterial fermentation, in the central nervous system may play a role in the regulation of intestinal...