Discovery of N-aryl sulphonamide-quinazoline derivatives as anti-gastric cancer agents in vitro and in vivo via activating the Hippo signalling pathway

• Main Authors: Jin-Bo Niu (Author), Chun-Hua Quan (Author), Yuan Liu (Author), Guang-Xi Yu (Author), Jia-Jia Yang (Author), Yin-Ru Li (Author), Yan-Bing Zhang (Author), Ying-Qiu Qi (Author), Jian Song (Author), Cheng-Yun Jin (Author), Sai-Yang Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hippo signalling pathway plays a crucial role in tumorigenesis and cancer progression. In this work, we identified an N-aryl sulphonamide-quinazoline derivative, compound 9i as an anti-gastric cancer agent, which exhibited potent antiproliferative ability with IC50 values of 0.36 μM (MGC-803 cells),...