pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial Cells

• Main Authors: Yu Sakurai (Author), Himeka Watanabe (Author), Kazuma Nishio (Author), Kohei Hashimoto (Author), Atsuki Harada (Author), Masaki Gomi (Author), Masayoshi Suzuki (Author), Ryotaro Oyama (Author), Takumi Handa (Author), Risa Sato (Author), Hina Takeuchi (Author), Ryoga Taira (Author), Kenta Tezuka (Author), Kota Tange (Author), Yuta Nakai (Author), Hidetaka Akita (Author), Yasuo Uchida (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The blood-brain barrier (BBB), which is comprised of brain capillary endothelial cells, plays a pivotal role in the transport of drugs from the blood to the brain. Therefore, an analysis of proteins in the endothelial cells, such as transporters and tight junction proteins, which contribute to BBB f...