Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells

• Main Authors: Devika P. Bagchi (Author), Akira Nishii (Author), Ziru Li (Author), Jennifer B. DelProposto (Author), Callie A. Corsa (Author), Hiroyuki Mori (Author), Julie Hardij (Author), Brian S. Learman (Author), Carey N. Lumeng (Author), Ormond A. MacDougald (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Canonical Wnt/β-catenin signaling is a well-studied endogenous regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and inhibiting adipogenesis. However, emerging genetic evidence in humans links a number of Wnt pathway members to body fat distribution, obesity,...