Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1α-Sirt1 Pathway

• Main Authors: Min-Yen Hsu (Author), Yai-Ping Hsiao (Author), Yu-Ta Lin (Author), Connie Chen (Author), Chee-Ming Lee (Author), Wen-Chieh Liao (Author), Shang-Chun Tsou (Author), Hui-Wen Lin (Author), Yuan-Yen Chang (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative damage of retinal pigment epithelium (RPE) cells plays an important role in the pathogenesis of blindness-related diseases, such as age-related macular degeneration (AMD). Quercetin, a bioactive flavonoid compound, has been shown to have a protective effect against oxidative stress-induced...