Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease

• Main Authors: Gaia Fancellu (Author), Karam Chand (Author), Daniel Tomás (Author), Elisabetta Orlandini (Author), Luca Piemontese (Author), Diana F. Silva (Author), Sandra M. Cardoso (Author), Sílvia Chaves (Author), M. Amélia Santos (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pursuing the widespread interest on multi-target drugs to combat Alzheimer´s disease (AD), a new series of hybrids was designed and developed based on the repositioning of the well-known acetylcholinesterase (AChE) inhibitor, tacrine (TAC), by its coupling to benzofuran (BF) derivatives. The BF fram...