Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage of experimental chromoblastomycosis.

• Main Authors: Isaque Medeiros Siqueira (Author), Marcel Wüthrich (Author), Mengyi Li (Author), Huafeng Wang (Author), Lucas de Oliveira Las-Casas (Author), Raffael Júnio Araújo de Castro (Author), Bruce Klein (Author), Anamelia Lorenzetti Bocca (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chromoblastomycosis (CBM) is a chronic worldwide subcutaneous mycosis, caused by several dimorphic, pigmented dematiaceous fungi. It is difficult to treat patients with the disease, mainly because of its recalcitrant nature. The correct activation of host immune response is critical to avoid fungal...