Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice

• Главные авторы: Lucienne Chatenoud (Автор), Cindy Marquet (Автор), Fabrice Valette (Автор), Lindsay Scott (Автор), Jiexia Quan (Автор), Chun Hui Bu (Автор), Sara Hildebrand (Автор), Eva Marie Y. Moresco (Автор), Jean-François Bach (Автор), Bruce Beutler (Автор)
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• Опубликовано: The Company of Biologists, 2022-06-01T00:00:00Z.
• Предметы: article
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Genetic association studies of type 1 diabetes (T1D) in humans, and in congenic non-obese diabetic (NOD) mice harboring DNA segments from T1D-resistant mice, face the challenge of assigning causation to specific gene variants among many within loci that affect disease risk. Here, we created random g...