Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice

• Main Authors: Lucienne Chatenoud (Author), Cindy Marquet (Author), Fabrice Valette (Author), Lindsay Scott (Author), Jiexia Quan (Author), Chun Hui Bu (Author), Sara Hildebrand (Author), Eva Marie Y. Moresco (Author), Jean-François Bach (Author), Bruce Beutler (Author)
• Format: Book
• Published: The Company of Biologists, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic association studies of type 1 diabetes (T1D) in humans, and in congenic non-obese diabetic (NOD) mice harboring DNA segments from T1D-resistant mice, face the challenge of assigning causation to specific gene variants among many within loci that affect disease risk. Here, we created random g...