Gut Clostridium sporogenes-derived indole propionic acid suppresses osteoclast formation by activating pregnane X receptor

• Main Authors: Renpeng Peng (Author), Chao Song (Author), Shuangquan Gou (Author), Haiyang Liu (Author), Honglei Kang (Author), Yimin Dong (Author), Yong Xu (Author), Peixuan Hu (Author), Kaiyong Cai (Author), Qian Feng (Author), Hanfeng Guan (Author), Feng Li (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone homeostasis is maintained by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. A dramatic decrease in estrogen levels in postmenopausal women leads to osteoclast overactivation, impaired bone homeostasis, and subsequent bone loss. Changes in the gut microbiome affect b...