Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola^® on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)

• Main Authors: Bart Hens (Author), Marival Bermejo (Author), Patrick Augustijns (Author), Rodrigo Cristofoletti (Author), Gregory E. Amidon (Author), Gordon L. Amidon (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present work, we explored if Coca-Cola^® had a beneficial impact on the systemic outcome of the weakly basic drug loratadine (Wal-itin^®, immediate-release formulation, 10 mg, generic drug product). To map the contribution of underlying physiologica...