Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola^® on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)

• Prif Awduron: Bart Hens (Awdur), Marival Bermejo (Awdur), Patrick Augustijns (Awdur), Rodrigo Cristofoletti (Awdur), Gregory E. Amidon (Awdur), Gordon L. Amidon (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2020-06-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

In the present work, we explored if Coca-Cola^® had a beneficial impact on the systemic outcome of the weakly basic drug loratadine (Wal-itin^®, immediate-release formulation, 10 mg, generic drug product). To map the contribution of underlying physiologica...