Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety

• Main Authors: Wei Gao (Author), Hongxiang Hu (Author), Lipeng Dai (Author), Miao He (Author), Hebao Yuan (Author), Huixia Zhang (Author), Jinhui Liao (Author), Bo Wen (Author), Yan Li (Author), Maria Palmisano (Author), Mohamed Dit Mady Traore (Author), Simon Zhou (Author), Duxin Sun (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug optimization, which improves drug potency/specificity by structure‒activity relationship (SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However, the current drug optimization may overlook the structure‒tissue exposure/selectivity-relations...