Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety
Drug optimization, which improves drug potency/specificity by structure‒activity relationship (SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However, the current drug optimization may overlook the structure‒tissue exposure/selectivity-relations...
Saved in:
Main Authors: | Wei Gao (Author), Hongxiang Hu (Author), Lipeng Dai (Author), Miao He (Author), Hebao Yuan (Author), Huixia Zhang (Author), Jinhui Liao (Author), Bo Wen (Author), Yan Li (Author), Maria Palmisano (Author), Mohamed Dit Mady Traore (Author), Simon Zhou (Author), Duxin Sun (Author) |
---|---|
Format: | Book |
Published: |
Elsevier,
2022-05-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Why 90% of clinical drug development fails and how to improve it?
by: Duxin Sun, et al.
Published: (2022) -
Application of Y-STR, DIP-STR and SNP-STR Markers in Interpretation of Forensic Genetic Profiling: A Narrative Review
by: Mehdi Forozesh, et al.
Published: (2022) -
Y-STR Kits and Y-STR diversity in the South African population: A review
by: Sthabile Shabalala, et al.
Published: (2022) -
Genetic polymorphisms of 16 X-STR loci in the Hani population from Southwest China
by: Linlin Liu, et al.
Published: (2021) -
Assessment of the forensic application of 50 Y-STR markers in a large pedigree
by: Yi Ye, et al.
Published: (2020)