Antimicrobial and Adjuvant Potencies of Di-<i>n</i>-alkyl Substituted Diazalariat Ethers

• Main Authors: Mohit B. Patel (Author), Helena Spikes (Author), Robert S. Bailey (Author), Thomas Connell (Author), Hannah Gill (Author), Michael R. Gokel (Author), Rebecca Harris (Author), Joseph W. Meisel (Author), Saeedeh Negin (Author), Shanheng Andrew Yin (Author), George W. Gokel (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lariat ethers are macrocyclic polyethers-crown ethers-to which sidearms are appended. 4,13-Diaza-18-crown-6 having twin alkyl chains at the nitrogens show biological activity. They exhibit antibiotic activity, but when co-administered at with an FDA-approved antibiotic, the latter's potency is...