Antimicrobial and Adjuvant Potencies of Di-<i>n</i>-alkyl Substituted Diazalariat Ethers

• Главные авторы: Mohit B. Patel (Автор), Helena Spikes (Автор), Robert S. Bailey (Автор), Thomas Connell (Автор), Hannah Gill (Автор), Michael R. Gokel (Автор), Rebecca Harris (Автор), Joseph W. Meisel (Автор), Saeedeh Negin (Автор), Shanheng Andrew Yin (Автор), George W. Gokel (Автор)
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• Опубликовано: MDPI AG, 2023-10-01T00:00:00Z.
• Предметы: article
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Lariat ethers are macrocyclic polyethers-crown ethers-to which sidearms are appended. 4,13-Diaza-18-crown-6 having twin alkyl chains at the nitrogens show biological activity. They exhibit antibiotic activity, but when co-administered at with an FDA-approved antibiotic, the latter's potency is...