High Concentrations of Uric Acid and Angiotensin II Act Additively to Produce Endothelial Injury

• Main Authors: Quan Hong (Author), Liyuan Wang (Author), Zhiyong Huang (Author), Zhe Feng (Author), Shaoyuan Cui (Author), Bo Fu (Author), Guangyan Cai (Author), Xiangmei Chen (Author), Di Wu (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Renin angiotensin (Ang) system (RAS) activation in metabolic syndrome (MS) patients is associated with elevated uric acid (UA) levels, resulting in endothelial system dysfunction. Our previous study demonstrated that excessive UA could cause endothelial injury through the aldose reductase (AR) pathw...