Structure-based virtual screening and molecular dynamics of potential inhibitors targeting sodium-bile acid co-transporter of carcinogenic liver fluke Clonorchis sinensis.

• Prif Awduron: Won Gi Yoo (Awdur), Fuhong Dai (Awdur), Jhang Ho Pak (Awdur), Sung-Jong Hong (Awdur), Jin-Ho Song (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Public Library of Science (PLoS), 2022-11-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

<h4>Background</h4>Clonorchis sinensis requires bile acid transporters as this fluke inhabits bile juice-filled biliary ducts, which provide an extreme environment. Clonorchis sinensis sodium-bile acid co-transporter (CsSBAT) is indispensable for the fluke's survival in the final ho...