Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions

• Main Authors: Helena Leonie Hanae Loer (Author), Denise Feick (Author), Simeon Rüdesheim (Author), Dominik Selzer (Author), Matthias Schwab (Author), Donato Teutonico (Author), Sebastian Frechen (Author), Maaike van derLee (Author), Dirk Jan A. R. Moes (Author), Jesse J. Swen (Author), Thorsten Lehr (Author)
• Format: Book
• Published: Wiley, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The immunosuppressant and narrow therapeutic index drug tacrolimus is metabolized mainly via cytochrome P450 (CYP) 3A4 and CYP3A5. For its pharmacokinetics (PK), high inter‐ and intra‐individual variability can be observed. Underlying causes include the effect of food intake on tacrolimus a...