Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions

• Main Authors: David Ngo (Author), Angel J. Magaña (Author), Tung Tran (Author), Jan Sklenicka (Author), Kimberly Phan (Author), Brian Eykholt (Author), Verónica Jimenez (Author), María S. Ramirez (Author), Marcelo E. Tolmasky (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plazomicin is a recent U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists of a sisomicin scaffold modified by adding a 2(S)-hydroxy aminobutyryl group at the N1 position and a hydroxyethyl substituent at the 6' position. These substitutions pro...