Hydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE - Coalition V): A double-blind, multicentre, randomised, controlled trial

• Main Authors: Álvaro Avezum (Author), Gustavo B F Oliveira (Author), Haliton Oliveira (Author), Rosa C Lucchetta (Author), Valéria F A Pereira (Author), André L Dabarian (Author), Ricardo D´O Vieira (Author), Daniel V Silva (Author), Adrian P M Kormann (Author), Alexandre P Tognon (Author), Ricardo De Gasperi (Author), Mauro E Hernandes (Author), Audes D M Feitosa (Author), Agnaldo Piscopo (Author), André S Souza (Author), Carlos H Miguel (Author), Vinicius O Nogueira (Author), César Minelli (Author), Carlos C Magalhães (Author), Karen M L Morejon (Author), Letícia S Bicudo (Author), Germano E C Souza (Author), Marco A M Gomes (Author), José J F Raposo Fo (Author), Alexandre V Schwarzbold (Author), Alexandre Zilli (Author), Roberto B Amazonas (Author), Frederico R Moreira (Author), Lucas B O Alves (Author), Silvia R L Assis (Author), Precil D M M Neves (Author), Jessica Y Matuoka (Author), Icaro Boszczowski (Author), Daniela G M Catarino (Author), Viviane C Veiga (Author), Luciano C P Azevedo (Author), Regis G Rosa (Author), Renato D Lopes (Author), Alexandre B Cavalcanti (Author), Otavio Berwanger (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Background: Previous Randomised controlled trials (RCT) evaluating chloroquine and hydroxychloroquine in non-hospitalised COVID-19 patients have found no significant difference in hospitalisation rates. However, low statistical power precluded definitive answers. Methods: We conducted a mul...