A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel

• Main Authors: Shoko Kakusaka (Author), Mahoko Asayama (Author), Asami Kaihara (Author), Tetsuo Sasano (Author), Takeshi Suzuki (Author), Junko Kurokawa (Author), Tetsushi Furukawa (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We recently reported that physiological concentrations of 17β-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K+ currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogens have the same effect as that of 17β-estradiol, we inv...