A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel

• Hauptverfasser: Shoko Kakusaka (Verfasst von), Mahoko Asayama (Verfasst von), Asami Kaihara (Verfasst von), Tetsuo Sasano (Verfasst von), Takeshi Suzuki (Verfasst von), Junko Kurokawa (Verfasst von), Tetsushi Furukawa (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2009-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

We recently reported that physiological concentrations of 17β-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K+ currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogens have the same effect as that of 17β-estradiol, we inv...