17-DMAG regulates p21 expression to induce chondrogenesis in vitro and in vivo

• Main Authors: Karri L. Bertram (Author), Nadia Narendran (Author), Pankaj Tailor (Author), Christina Jablonski (Author), Catherine Leonard (Author), Edward Irvine (Author), Ricarda Hess (Author), Anand O. Masson (Author), Saleem Abubacker (Author), Kristina Rinker (Author), Jeff Biernaskie (Author), Robin M. Yates (Author), Paul Salo (Author), Aru Narendran (Author), Roman J. Krawetz (Author)
• Format: Book
• Published: The Company of Biologists, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cartilage degeneration after injury affects a significant percentage of the population, including those that will go on to develop osteoarthritis (OA). Like humans, most mammals, including mice, are incapable of regenerating injured cartilage. Interestingly, it has previously been shown that p21 (Cd...