RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma

• Main Authors: Zhaoming Lu (Author), Xiaojing Shi (Author), Fanghua Gong (Author), Shenglei Li (Author), Yang Wang (Author), Yandan Ren (Author), Mengyin Zhang (Author), Bin Yu (Author), Yan Li (Author), Wen Zhao (Author), Jianying Zhang (Author), Guiqin Hou (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysregulation of mTORC1/mTORC2 pathway is observed in many cancers and mTORC1 inhibitors have been used clinically in many tumor types; however, the mechanism of mTORC2 in tumorigenesis is still obscure. Here, we mainly explored the potential role of mTORC2 in esophageal squamous cell carcinoma (ESC...