Inhibition of the IGF-1-PI3K-Akt-mTORC2 pathway in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis

• Main Authors: Tuba Sural-Fehr (Author), Harinder Singh (Author), Ludovico Cantuti-Catelvetri (Author), Hongling Zhu (Author), Michael S. Marshall (Author), Rima Rebiai (Author), Martin J. Jastrzebski (Author), Maria I. Givogri (Author), Mark M. Rasenick (Author), Ernesto R. Bongarzone (Author)
• Format: Book
• Published: The Company of Biologists, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glycosphingolipid (GSL) accumulation is implicated in the neuropathology of several lysosomal conditions, such as Krabbe disease, and may also contribute to neuronal and glial dysfunction in adult-onset conditions such as Parkinson's disease, Alzheimer's disease and multiple sclerosis. GSL...