All-Trans Retinoic Acid Modulates TLR4/NF-κB Signaling Pathway Targeting TNF-α and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer

• Main Authors: Hayet Rafa (Author), Sarra Benkhelifa (Author), Sonia AitYounes (Author), Houria Saoula (Author), Said Belhadef (Author), Mourad Belkhelfa (Author), Aziza Boukercha (Author), Ryma Toumi (Author), Imene Soufli (Author), Olivier Moralès (Author), Yvan de Launoit (Author), Hassen Mahfouf (Author), M'hamed Nakmouche (Author), Nadira Delhem (Author), Chafia Touil-Boukoffa (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colitis associated cancer (CAC) is the colorectal cancer (CRC) subtype that is associated with bowel disease such as ulcerative colitis (UC). The data on role of NF-κB signaling in development and progression of CAC were derived from preclinical studies, whereas data from human are rare. The aim of...