siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin

• Main Authors: Shuquan Zheng (Author), Xiaoxia Wang (Author), Yu-Hua Weng (Author), Xingyu Jin (Author), Jia-Li Ji (Author), Liangxia Guo (Author), Bo Hu (Author), Nan Liu (Author), Qiang Cheng (Author), Jianqi Zhang (Author), Huicheng Bai (Author), Tongren Yang (Author), Xin-Hua Xia (Author), Hong-Yan Zhang (Author), Shan Gao (Author), Yuanyu Huang (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic cancer is currently one of the deadliest of the solid malignancies, whose incidence and death rates are increasing consistently during the past 30 years. Ribonucleotide reductase (RR) is a rate-limiting enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides, whic...