Rapid and validated UHPLC method for simultaneous determination of sofosbuvir, ledipasvir and paracetamol as commonly repurposed drugs for COVID-19 treatment: application in spiked human plasma

• Главные авторы: Sherif Gamal (Автор), Gehad G. Mohamed (Автор), Said A. Salih (Автор), Menna I. Ezzeldin (Автор), Asmaa A. Mandour (Автор)
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• Опубликовано: SpringerOpen, 2023-10-01T00:00:00Z.
• Предметы: article
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Abstract Background Sofosbuvir/ledipasvir (SOF/LDV), a combination of antiviral drugs, has been recently repurposed for COVID-19 management, according to Food and Drug Administration approval. Paracetamol (PAR) identified as a first-line antipyretic for COVID-19 symptoms' management. The use of...