Novel subcellular localization for alpha-synuclein: possible functional consequences

• Main Authors: Cristina eGuardia-Laguarta (Author), Estela eArea-Gomez (Author), Eric A Schon (Author), Serge ePrzedborski (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

α−Synuclein (α-syn) is one of the genes that when mutated or overexpressed causes Parkinson's Disease (PD). Initially, it was described as a synaptic terminal protein and later was found to be localized at mitochondria. Mitochondria-associated membranes (MAM) have emerged as a central endoplasm...