Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway

• Auteurs principaux: Xiaoye Fan (Auteur), Wei Wei (Auteur), Jingbo Huang (Auteur), Xingkai Liu (Auteur), Xinxin Ci (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Cisplatin (CDDP) is a widely used chemotherapeutic agent for various solid tumors, but its severe side effects, particularly nephrotoxicity, limit its clinical application. Isoorientin (Iso) is a flavonoid-like compound known to have antioxidant effects. As oxidative injury plays a vital role in CDD...