Lipid nanoparticle-encapsulated, chemically modified anti-adenoviral siRNAs inhibit hepatic adenovirus infection in immunosuppressed Syrian hamsters

• Hoofdauteurs: Anja Geisler (Auteur), Babette Dieringer (Auteur), Leslie Elsner (Auteur), Karin Klingel (Auteur), Robert Klopfleisch (Auteur), Hans-Peter Vornlocher (Auteur), Jens Kurreck (Auteur), Henry Fechner (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2023-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

RNA interference has demonstrated its potential as an antiviral therapy for treatment of human adenovirus (hAd) infections. The only existing viral vector-based system for delivery of anti-adenoviral artificial microRNAs available for in vivo use, however, has proven to be inefficient in therapeutic...