Lipid nanoparticle-encapsulated, chemically modified anti-adenoviral siRNAs inhibit hepatic adenovirus infection in immunosuppressed Syrian hamsters

• Main Authors: Anja Geisler (Author), Babette Dieringer (Author), Leslie Elsner (Author), Karin Klingel (Author), Robert Klopfleisch (Author), Hans-Peter Vornlocher (Author), Jens Kurreck (Author), Henry Fechner (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNA interference has demonstrated its potential as an antiviral therapy for treatment of human adenovirus (hAd) infections. The only existing viral vector-based system for delivery of anti-adenoviral artificial microRNAs available for in vivo use, however, has proven to be inefficient in therapeutic...