A bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3

• Main Authors: Alexander Rau (Author), Katharina Kocher (Author), Mirjam Rommel (Author), Lennart Kühl (Author), Maximilian Albrecht (Author), Hannes Gotthard (Author), Nadine Aschmoneit (Author), Bettina Noll (Author), Monilola A. Olayioye (Author), Roland E. Kontermann (Author), Oliver Seifert (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dual targeting of surface receptors with bispecific antibodies is attracting increasing interest in cancer therapy. Here, we present a novel bivalent and bispecific antagonistic molecule (Dab-Fc) targeting human epidermal growth factors 2 and 3 (HER2 and HER3) derived from the Db-Ig platform, which...