Novel sulfonamide benzoquinazolinones as dual EGFR/HER2 inhibitors, apoptosis inducers and radiosensitizers

• Main Authors: Aiten M. Soliman (Author), Ali S. Alqahtani (Author), Mostafa M. Ghorab (Author)
• 格式: 图书
• 出版: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

A series of sulfonamide benzoquinazolinones 5-18 was synthesized and evaluated for cytotoxic activity against MDA-MB-231 cell line. The compounds showed IC50 ranging from 0.26 to 161.49 µM. The promising compounds were evaluated for their inhibitory profile against epidermal growth factor (EGFR) and...