Cover Image

Novel sulfonamide benzoquinazolinones as dual EGFR/HER2 inhibitors, apoptosis inducers and radiosensitizers

A series of sulfonamide benzoquinazolinones 5-18 was synthesized and evaluated for cytotoxic activity against MDA-MB-231 cell line. The compounds showed IC50 ranging from 0.26 to 161.49 µM. The promising compounds were evaluated for their inhibitory profile against epidermal growth factor (EGFR) and...

Full description

Saved in:

Bibliographic Details
Main Authors:	Aiten M. Soliman (Author), Ali S. Alqahtani (Author), Mostafa M. Ghorab (Author)
Format:	Book
Published:	Taylor & Francis Group, 2019-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers
by: Mostafa M. Ghorab, et al.
Published: (2021)

Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors
by: Mostafa M. Ghorab, et al.
Published: (2018)

VEGFR-2 inhibitors and apoptosis inducers: synthesis and molecular design of new benzo[g]quinazolin bearing benzenesulfonamide moiety
by: Mostafa M. Ghorab, et al.
Published: (2017)

Identification of potential therapeutic dual inhibitors of EGFR/HER2 in breast cancer
by: Megha Jethwa, et al.
Published: (2024)

Design, Synthesis, and Biological Evaluation of Sulfonamide Methoxypyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors
by: Haotian Gao, et al.
Published: (2023)

Discovery of Potent Dual EGFR/HER2 Inhibitors Based on Thiophene Scaffold Targeting H1299 Lung Cancer Cell Line
by: Ranza Elrayess, et al.
Published: (2020)

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R
by: Cornelius Hempel, et al.
Published: (2017)

Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent
by: Liu W, et al.
Published: (2015)

AT-406, an IAP Inhibitor, Activates Apoptosis and Induces Radiosensitization of Normoxic and Hypoxic Cervical Cancer Cells
by: Jing Lu, et al.
Published: (2014)

Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights
by: Abdelgawad MA, et al.
Published: (2021)

Virtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma
by: Feng YQ, et al.
Published: (2020)

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
by: Moataz A. Shaldam, et al.
Published: (2023)

Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors
by: Lamya H. Al-Wahaibi, et al.
Published: (2022)

Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study
by: Dina I.A. Othman, et al.
Published: (2023)

Novel thienopyrimidine derivatives as dual EGFR and VEGFR-2 inhibitors: design, synthesis, anticancer activity and effect on cell cycle profile
by: Aml E.-S. Mghwary, et al.
Published: (2019)

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance
by: Tim Fischer, et al.
Published: (2018)

Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles
by: Shenghua Gao, et al.
Published: (2023)

Design and Development of Novel Urea, Sulfonyltriurea, and Sulfonamide Derivatives as Potential Inhibitors of Sphingosine Kinase 1
by: Sonam Roy, et al.
Published: (2020)

Indoline-6-Sulfonamide Inhibitors of the Bacterial Enzyme DapE
by: Cory T. Reidl, et al.
Published: (2020)

Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer
by: Esraa A. Abdelsalam, et al.
Published: (2022)

Novel sulphonamide-bearing methoxyquinazolinone derivatives as anticancer and apoptosis inducers: synthesis, biological evaluation and in silico studies
by: Ali S. Alqahtani, et al.
Published: (2022)

Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer
by: Zhehong Zhu, et al.
Published: (2021)

Discovery of Putative Dual Inhibitor of Tubulin and EGFR by Phenotypic Approach on LASSBio-1586 Homologs
by: Gisele Barbosa, et al.
Published: (2022)

Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors
by: Suleyman Akocak, et al.
Published: (2018)

Sulfonamide Allergies
by: Amber Giles, et al.
Published: (2019)

In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II
by: Mohamed Badr, et al.
Published: (2024)

Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2',3':4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity
by: Mai A. E. Mourad, et al.
Published: (2023)

Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme
by: Atilla Akdemir, et al.
Published: (2019)

In Vitro Anticancer Activity Screening of Novel Fused Thiophene Derivatives as VEGFR-2/AKT Dual Inhibitors and Apoptosis Inducers
by: Rana M. Abdelnaby, et al.
Published: (2022)

Correction to: Fischer et al., Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance
Published: (2018)

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights
by: Mostafa M. Elbadawi, et al.
Published: (2022)

Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi
by: Alane Beatriz Vermelho, et al.
Published: (2018)

Design, Synthesis and Biological Evaluation of Aromatase Inhibitors Based on Sulfonates and Sulfonamides of Resveratrol
by: Marialuigia Fantacuzzi, et al.
Published: (2021)

Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity
by: Amr Sonousi, et al.
Published: (2022)

Synthesis, Docking, and DFT Studies on Novel Schiff Base Sulfonamide Analogues as Selective COX-1 Inhibitors with Anti-Platelet Aggregation Activity
by: Yasmine M. Abdel Aziz, et al.
Published: (2024)

Microdosimetric Investigation and a Novel Model of Radiosensitization in the Presence of Metallic Nanoparticles
by: Huagang Yan, et al.
Published: (2021)

Bcl-xL DNAzymes promote radiosensitivity and chemosensitivity in colorectal cancer cells via enhancing apoptosis
by: Zhen Yu, et al.
Published: (2022)

Radiosensitizers, radioprotectors, and radiation mitigators
by: Jayam Raviraj, et al.
Published: (2014)

Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells
by: Alisha T. Poole, et al.
Published: (2020)

A Novel Dual-Payload ADC for the Treatment of HER2+ Breast and Colon Cancer
by: Candice Maria Mckertish, et al.
Published: (2023)