NSAIDs: Old Drugs Reveal New Anticancer Targets

• Main Authors: Gary A. Piazza (Author), Adam B. Keeton (Author), Heather N. Tinsley (Author), Jason D. Whitt (Author), Bernard D. Gary (Author), Bini Mathew (Author), Raj Singh (Author), William E. Grizzle (Author), Robert C. Reynolds (Author)
• Format: Book
• Published: MDPI AG, 2010-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is compelling evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 selective inhibitors have antineoplastic activity, but toxicity from cyclooxygenase (COX) inhibition and the suppression of physiologically important prostaglandins limits their use for cancer chemop...