Pharmacokinetic interaction between single and multiple doses of darunavir, in combination with cobicistat or ritonavir, and single-dose dabigatran etexilate in healthy adults

• Main Authors: Sandy Van Hemelryck (Author), Erika Van Landuyt (Author), Jay Ariyawansa (Author), Martyn Palmer (Author), Martine J. C. Kothe (Author), Caroline Pollefliet (Author)
• Format: Book
• Published: SpringerOpen, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Objective Darunavir (DRV) is a P-glycoprotein (P-gp) inhibitor. Dabigatran etexilate, prodrug of the anticoagulant dabigatran, is a P-gp probe substrate. This study evaluated the effect of single and multiple doses of DRV, coadministered with cobicistat (COBI) or ritonavir (rtv), on the pha...