Pharmacokinetic interaction between single and multiple doses of darunavir, in combination with cobicistat or ritonavir, and single-dose dabigatran etexilate in healthy adults
Abstract Objective Darunavir (DRV) is a P-glycoprotein (P-gp) inhibitor. Dabigatran etexilate, prodrug of the anticoagulant dabigatran, is a P-gp probe substrate. This study evaluated the effect of single and multiple doses of DRV, coadministered with cobicistat (COBI) or ritonavir (rtv), on the pha...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
SpringerOpen,
2024-10-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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