Animal Models to Study the Mutational Landscape for Oral Cavity and Oropharyngeal Cancers

• Main Authors: Michael T. Spiotto (Author), Matthew Pytynia (Author), Gene-Fu F. Liu (Author), Mark C. Ranck (Author), Ryan Widau (Author)
• Format: Book
• Published: Stilus Optimus, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Cancer is likely caused by alterations in gene structure or expression. Recently, next generation sequencing has documented mutations in 106 head and neck squamous cell cancer genomes, suggesting several new candidate genes. However, it remains difficult to determine which mutations dire...