Animal Models to Study the Mutational Landscape for Oral Cavity and Oropharyngeal Cancers

• Ngā kaituhi matua: Michael T. Spiotto (Author), Matthew Pytynia (Author), Gene-Fu F. Liu (Author), Mark C. Ranck (Author), Ryan Widau (Author)
• Hōputu: Pukapuka
• I whakaputaina: Stilus Optimus, 2013-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Objectives: Cancer is likely caused by alterations in gene structure or expression. Recently, next generation sequencing has documented mutations in 106 head and neck squamous cell cancer genomes, suggesting several new candidate genes. However, it remains difficult to determine which mutations dire...