Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

• Main Authors: Marival Bermejo (Author), Gislaine Kuminek (Author), Jozef Al-Gousous (Author), Alejandro Ruiz-Picazo (Author), Yasuhiro Tsume (Author), Alfredo Garcia-Arieta (Author), Isabel González-Alvarez (Author), Bart Hens (Author), Gregory E. Amidon (Author), Nair Rodriguez-Hornedo (Author), Gordon L. Amidon (Author), Deanna Mudie (Author)
• Format: Book
• Published: MDPI AG, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present work aimed to explain the differences in oral performance in fasted humans who were categorized into groups based on the three different drug product formulations of dexketoprofen trometamol (DKT) salt—Using a combination of in vitro techniques and pharmacokinetic analysis. The non-bioeq...