Optimization of Sonotrode Ultrasonic-Assisted Extraction of Proanthocyanidins from Brewers' Spent Grains

Brewing spent grains (BSGs) are the main by-product from breweries and they are rich of proanthocyanidins, among other phenolic compounds. However, literature on these compounds in BSGs is scarce. Thus, this research focuses on the establishment of ultrasound-assisted extraction of proanthocyanidin...

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Main Authors: Beatriz Martín-García (Author), Federica Pasini (Author), Vito Verardo (Author), Elixabet Díaz- (Author), Urszula Tylewicz (Author), Ana María Gómez-Caravaca (Author), Maria Fiorenza Caboni (Author)
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Published: MDPI AG, 2019-08-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Beatriz Martín-García  |e author 
700 1 0 |a Federica Pasini  |e author 
700 1 0 |a Vito Verardo  |e author 
700 1 0 |a Elixabet Díaz-  |e author 
700 1 0 |a Urszula Tylewicz  |e author 
700 1 0 |a Ana María Gómez-Caravaca  |e author 
700 1 0 |a Maria Fiorenza Caboni  |e author 
245 0 0 |a Optimization of Sonotrode Ultrasonic-Assisted Extraction of Proanthocyanidins from Brewers' Spent Grains 
260 |b MDPI AG,   |c 2019-08-01T00:00:00Z. 
500 |a 2076-3921 
500 |a 10.3390/antiox8080282 
520 |a Brewing spent grains (BSGs) are the main by-product from breweries and they are rich of proanthocyanidins, among other phenolic compounds. However, literature on these compounds in BSGs is scarce. Thus, this research focuses on the establishment of ultrasound-assisted extraction of proanthocyanidin compounds in brewing spent grains using a sonotrode. To set the sonotrode extraction up, response surface methodology (RSM) was used to study the effects of three factors, namely, solvent composition, time of extraction, and ultrasound power. Qualitative and quantitative analyses of proanthocyanidin compounds were performed using HPLC coupled to fluorometric and mass spectrometer detectors. The highest content of proanthocyanidins was obtained using 80/20 acetone/water (<i>v</i>/<i>v</i>), 55 min, and 400 W. The established method allows the extraction of 1.01 mg/g dry weight (d.w.) of pronthocyanidins from BSGs; this value is more than two times higher than conventional extraction. 
546 |a EN 
690 |a Box-Behnken design 
690 |a proanthocyanidins 
690 |a Brewers' spent grains 
690 |a sonotrode ultrasonic-assisted extraction 
690 |a HPLC-fluorometric detector (FLD)-MS 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antioxidants, Vol 8, Iss 8, p 282 (2019) 
787 0 |n https://www.mdpi.com/2076-3921/8/8/282 
787 0 |n https://doaj.org/toc/2076-3921 
856 4 1 |u https://doaj.org/article/8fa3ad2c9964482f9d91b206878c06e5  |z Connect to this object online.