Safety, Pharmacokinetics, and Pharmacodynamics of a Single Bolus of the γ-aminobutyric Acid (GABA) Receptor Potentiator HSK3486 in Healthy Chinese Elderly and Non-elderly

• Main Authors: Xiaojiao Li (Author), Deming Yang (Author), Qianqian Li (Author), Hong Wang (Author), Meng Wang (Author), Pangke Yan (Author), Nan Wu (Author), Fangqiong Li (Author), Shiping Ma (Author), Yanhua Ding (Author), Jingrui Liu (Author), Hushan Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The present clinical trial investigated the potential influences of dosage and age on the pharmacokinetic properties and safety profile of HSK3486, and whether any adjustment in dosing regimen is necessary in elderly patients.Methods: Twenty-four elderly participants (65-73 years) were a...