Cover Image

Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT

In the current study, we identified a mechanism of resveratrol (RES) underlying its anti-cancer properties against human ovarian adenocarcinoma SKOV-3 cells. We investigated its anti-proliferative and apoptosis-inducing effects in combination with cisplatin, using cell viability assay, flow cytometr...

Full description

Saved in:

Bibliographic Details
Main Authors:	Phateep Hankittichai (Author), Phatarawat Thaklaewphan (Author), Nitwara Wikan (Author), Jirapak Ruttanapattanakul (Author), Saranyapin Potikanond (Author), Duncan R. Smith (Author), Wutigri Nimlamool (Author)
Format:	Book
Published:	MDPI AG, 2023-05-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Oxyresveratrol Inhibits TNF-α-Stimulated Cell Proliferation in Human Immortalized Keratinocytes (HaCaT) by Suppressing AKT Activation
by: Nitwara Wikan, et al.
Published: (2021)

Molecular Targets of Pinocembrin Underlying Its Regenerative Activities in Human Keratinocytes
by: Jirapak Ruttanapattanakul, et al.
Published: (2022)

Alpinetin Suppresses Zika Virus-Induced Interleukin-1β Production and Secretion in Human Macrophages
by: Nitwara Wikan, et al.
Published: (2022)

Anti-cancer effects of Kaempferia parviflora on ovarian cancer SKOV3 cells
by: Suthasinee Paramee, et al.
Published: (2018)

Kaempferia parviflora Extract Exhibits Anti-cancer Activity against HeLa Cervical Cancer Cells
by: Saranyapin Potikanond, et al.
Published: (2017)

Pharmacological Benefits of Triphala: A Perspective for Allergic Rhinitis
by: Salinee Jantrapirom, et al.
Published: (2021)

Resveratrol, Acetyl-Resveratrol, and Polydatin Exhibit Antigrowth Activity against 3D Cell Aggregates of the SKOV-3 and OVCAR-8 Ovarian Cancer Cell Lines
by: Simon J. Hogg, et al.
Published: (2015)

Resistomycin Induced Apoptosis and Cycle Arrest in Human Hepatocellular Carcinoma Cells by Activating p38 MAPK Pathway In Vitro and In Vivo
by: Zhuo Han, et al.
Published: (2021)

Myricetin Induces Autophagy and Cell Cycle Arrest of HCC by Inhibiting MARCH1-Regulated Stat3 and p38 MAPK Signaling Pathways
by: Wei Yang, et al.
Published: (2021)

Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway
by: Chao Li, et al.
Published: (2019)

Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest
by: Mahban Rahimifard, et al.
Published: (2023)

Alantolactone and ZnO nanoparticles induce apoptosis activity of cisplatin in an ovarian cancer cell line (SKOV3)
by: Shahriar Alipour, et al.
Published: (2022)

Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3)
by: Mohammed S. Aleissa, et al.
Published: (2023)

MAPK p38alpha Kinase Influences Haematopoiesis in Embryonic Stem Cells
by: Kateřina Štefková, et al.
Published: (2019)

Unraveling the Catha edulis Extract Effects on the Cellular and Molecular Signaling in SKOV3 Cells
by: Alaa Sayed Abou-Elhamd, et al.
Published: (2021)

Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway
by: Hongtao He, et al.
Published: (2021)

Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts
by: Terence Davis, et al.
Published: (2016)

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
by: Pan ST, et al.
Published: (2015)

Cytotoxicity of Standardized Curcuminoids Mixture against Epithelial Ovarian Cancer Cell Line SKOV-3
by: Heba Almosa, et al.
Published: (2020)

Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity against SKOV-3 Ovarian Cancer Cells
by: Usama A. Fahmy, et al.
Published: (2020)

SITOTOKSISITAS EKSTRAK DAUN CIPLUKAN (Physalis angulata) PADA SEL KANKER OVARIUM (SKOV3 CELL-LINES)
by: Anggi Meinawan Insanie, _
Published: (2018)

Human monocytes differentiate into tumor-associated macrophages upon SKOV3 cells coculture and/or lysophosphatidic acid stimulation
by: Ying Feng, et al.
Published: (2022)

Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways
by: Minjie Zhang, et al.
Published: (2021)

p38 MAPK, microglial signaling, and neuropathic pain
by: Suter Marc R, et al.
Published: (2007)

Attenuation of High Glucose-Induced Damage in RPE Cells through p38 MAPK Signaling Pathway Inhibition
by: Grazia Maugeri, et al.
Published: (2021)

Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways
by: Haojie Liu, et al.
Published: (2017)

Pharmacological p38 MAPK inhibitor SB203580 enhances AML stem cell line KG1a chemosensitivity to daunorubicin by promoting late apoptosis, cell growth arrest in S-phase, and miR-328-3p upregulation
by: Sara Bahattab, et al.
Published: (2024)

The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells
by: Li JP, et al.
Published: (2015)

Glycolysis inhibition via mTOR suppression is a key step in cardamonin-induced autophagy in SKOV3 cells
by: Daohua Shi, et al.
Published: (2018)

Autophagy Inhibits Inflammation via Down-Regulation of p38 MAPK/mTOR Signaling Cascade in Endothelial Cells
by: Zhou L, et al.
Published: (2023)

Tobramycin Promotes Melanogenesis by Upregulating p38 MAPK Protein Phosphorylation in B16F10 Melanoma Cells
by: Seung-Hyun Moon, et al.
Published: (2019)

Sevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling Pathway
by: Kang K, et al.
Published: (2019)

Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling
by: Yong-Heng Luo, et al.
Published: (2018)

Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1
by: Lihua Wang, et al.
Published: (2020)

Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway
by: Xiang Qin, et al.
Published: (2022)

Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome
by: Mark C. Bagley, et al.
Published: (2010)

α-Mangostin-phytosomes as a plausible nano-vesicular approach for enhancing cytotoxic activity on SKOV-3 ovarian cancer cells
by: Abdulmohsin J. Alamoudi, et al.
Published: (2024)

Adenine Combined with Cisplatin Promotes Anticancer Activity against Hepatocellular Cancer Cells through AMPK-Mediated p53/p21 and p38 MAPK Cascades
by: Jhen-Yu Huang, et al.
Published: (2022)

2,6-DMBQ suppresses cell proliferation and migration via inhibiting mTOR/AKT and p38 MAPK signaling pathways in NSCLC cells
by: Xiaomeng Xie, et al.
Published: (2021)

Diarachidonoylphosphoethanolamine induces apoptosis of malignant pleural mesothelioma cells through a Trx/ASK1/p38 MAPK pathway
by: Ayako Tsuchiya, et al.
Published: (2015)