Anti-Tumor Efficiency of Perillylalcohol/β-Cyclodextrin Inclusion Complexes in a Sarcoma S180-Induced Mice Model

• Main Authors: Allan A. Rezende (Author), Rafael S. Santos (Author), Luciana N. Andrade (Author), Ricardo G. Amaral (Author), Matheus M. Pereira (Author), Cristiane Bani (Author), Mo Chen (Author), Ronny Priefer (Author), Classius F. da Silva (Author), Ricardo L. C. de Albuquerque Júnior (Author), Eliana B. Souto (Author), Patrícia Severino (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The low solubility and high volatility of perillyl alcohol (POH) compromise its bioavailability and potential use as chemotherapeutic drug. In this work, we have evaluated the anticancer activity of POH complexed with β-cyclodextrin (β-CD) using three complexation approaches. Molecular docking sugge...