A transcriptional signature detects homologous recombination deficiency in pancreatic cancer at the individual level

• Main Authors: Shuping Zhuang (Author), Tingting Chen (Author), Yawei Li (Author), Yuquan Wang (Author), Liqiang Ai (Author), Yiding Geng (Author), Min Zou (Author), Kaidong Liu (Author), Huanhuan Xu (Author), Linzhu Wang (Author), Zhangxiang Zhao (Author), Zhiqiang Chang (Author), Yunyan Gu (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic cancer (PC) with homologous recombination deficiency (HRD) has been reported to benefit from poly ADP-ribose polymerase (PARP) inhibitors. However, accurate identification of HRD status for PC patients from the transcriptional level is still a great challenge. Here, based on a relative ex...