Unique Cellular and Biochemical Features of Human Mitochondrial Peroxiredoxin 3 Establish the Molecular Basis for Its Specific Reaction with Thiostrepton

• Main Authors: Kimberly J. Nelson (Author), Terri Messier (Author), Stephanie Milczarek (Author), Alexis Saaman (Author), Stacie Beuschel (Author), Uma Gandhi (Author), Nicholas Heintz (Author), Terrence L. Smalley (Author), W. Todd Lowther (Author), Brian Cunniff (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A central hallmark of tumorigenesis is metabolic alterations that increase mitochondrial reactive oxygen species (mROS). In response, cancer cells upregulate their antioxidant capacity and redox-responsive signaling pathways. A promising chemotherapeutic approach is to increase ROS to levels incompa...